Tumours arise as the result of the accumulation of genetic mutations in cells. As a result, the regulation of cellular processes such as growth, division, migration, and energy metabolism are disrupted, allowing cancers to grow from one cell into a tumour and spread.

One of CCRC's goals is to understand the difference in the genetic and molecular mechanisms between normal and cancer cells. This knowledge is required to develop better cancer therapies, and improved diagnostic, prognostic, and treatment strategies. The CCRC is employing a multi-disciplinary approach to understand the biology of normal cells, and to use this knowledge to effectively fight cancer.

Dr Sharon McKenna has worked at developing an improved understanding of the resistance mechanisms employed by leukaemia cancer cells that makes them resistant to chemotherapy and radiotherapy. This work will hopefully in time lead to new drugs that can target the leukaemia cells specifically without damaging healthy cells.