Cancer Genetics & Biology
Tumours arise as the result of the accumulation of genetic mutations in cells. As a result, the regulation of cellular processes such as growth, division, migration, and energy metabolism are disrupted, allowing cancers to grow from one cell into a tumour and spread.
[Oesophageal cancer cells treated with 5-Flurouracil and labelled with an autophagy marker GFP-LC3. Cells show accumulation of vesicles, indicating induction of autophagy] One of CCRC's goals is to understand the difference in the genetic and molecular mechanisms between normal and cancer cells. This knowledge is required to develop better cancer therapies, and improved diagnostic, prognostic, and treatment strategies. The CCRC is employing a multi-disciplinary approach to understand the biology of normal cells, and to use this knowledge to effectively fight cancer.
The Autophagy Team at CCRC are working on understanding the role of autophagy on chemotherapeutic resistance and developing new approaches to promote the demise of drug resistant cancer cells. We are looking at bio-markers of autophagic responses and evaluating new regulators of cell death and survival pathways as potential drug targets. The ultimate aim of this research is to develop novel therapeutic approaches and significantly improve outcome for cancer patients.